abstract：BACKGROUND & AIMS:Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) lower the risk of colorectal cancer (CRC). We investigated whether plasma inflammatory markers were associated with risk of CRC and if use of anti-inflammatory drugs was differentially associated with risk of CRC according to levels of inflamma...

journal_title：Gastroenterology

authors： Chan AT,Ogino S,Giovannucci EL,Fuchs CS

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND & AIMS:Rabs are monomeric guanosine triphosphatases that regulate membrane trafficking and acid secretion in gastric parietal cells. Using a proteomics approach, we identified a new Rab, Rab27b, in tubulovesicle membranes and determined its role in parietal cell activation. METHODS:We used mass spectrometry...

journal_title：Gastroenterology

authors： Suda J,Zhu L,Okamoto CT,Karvar S

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND & AIMS:Several small molecule inhibitors of the hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease have advanced successfully to clinical trials. However, the selection of drug-resistant mutants is a significant issue with protease inhibitors (PIs). A variety of amino acid substitutions in the ...

journal_title：Gastroenterology

authors： Shimakami T,Welsch C,Yamane D,McGivern DR,Yi M,Zeuzem S,Lemon SM

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND & AIMS:Krüppel-like factor 5 (KLF5) is a transcription factor that promotes proliferation, is highly expressed in dividing crypt cells of the gastrointestinal epithelium, and is induced by various stress stimuli. We sought to determine the role of KLF5 in colonic inflammation and recovery by studying mice wi...

journal_title：Gastroenterology

authors： McConnell BB,Kim SS,Bialkowska AB,Yu K,Sitaraman SV,Yang VW

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND & AIMS:Chemoembolization is one of several standards of care treatment for hepatocellular carcinoma (HCC). Radioembolization with Yttrium-90 microspheres is a novel, transarterial approach to radiation therapy. We performed a comparative effectiveness analysis of these therapies in patients with HCC. METHOD...

journal_title：Gastroenterology

authors： Salem R,Lewandowski RJ,Kulik L,Wang E,Riaz A,Ryu RK,Sato KT,Gupta R,Nikolaidis P,Miller FH,Yaghmai V,Ibrahim SM,Senthilnathan S,Baker T,Gates VL,Atassi B,Newman S,Memon K,Chen R,Vogelzang RL,Nemcek AA,Resnick SA

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND & AIMS:Chronic stress is associated with visceral hyperalgesia in functional gastrointestinal disorders. We investigated whether corticosterone plays a role in chronic psychological stress-induced visceral hyperalgesia. METHODS:Male rats were subjected to 1-hour water avoidance (WA) stress or subcutaneous c...

journal_title：Gastroenterology

authors： Hong S,Zheng G,Wu X,Snider NT,Owyang C,Wiley JW

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with Barrett's esophagus (BE) show increased risk of developing esophageal adenocarcinoma and are routinely examined using upper endoscopy with biopsy to detect neoplastic changes. Angle-resolved low coherence interferometry (a/LCI) uses in vivo depth-resolved nuclear morphology measurements ...

journal_title：Gastroenterology

authors： Terry NG,Zhu Y,Rinehart MT,Brown WJ,Gebhart SC,Bright S,Carretta E,Ziefle CG,Panjehpour M,Galanko J,Madanick RD,Dellon ES,Trembath D,Bennett A,Goldblum JR,Overholt BF,Woosley JT,Shaheen NJ,Wax A

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND & AIMS:Gastroesophageal reflux is common among patients with postnasal drainage. We investigated whether proton pump inhibitor therapy improved symptoms in patients with postnasal drainage without sinusitis or allergies. METHODS:In a parallel-group, double-blind, multi-specialty trial, we randomly assigned ...

journal_title：Gastroenterology

authors： Vaezi MF,Hagaman DD,Slaughter JC,Tanner SB,Duncavage JA,Allocco CT,Sparkman C,Clement LE,Wasden CM,Wirth D,Goutte M,McCafferty BA,Lanza DC

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND & AIMS:A single nucleotide polymorphism (SNP) upstream of the IL28B gene has been associated with response of patients with chronic hepatitis C to therapy with pegylated interferon and ribavirin and also with spontaneous clearance of acute hepatitis C in a heterogeneous population. We analyzed the associatio...

journal_title：Gastroenterology

authors： Tillmann HL,Thompson AJ,Patel K,Wiese M,Tenckhoff H,Nischalke HD,Lokhnygina Y,Kullig U,Göbel U,Capka E,Wiegand J,Schiefke I,Güthoff W,Grüngreiff K,König I,Spengler U,McCarthy J,Shianna KV,Goldstein DB,McHutchison JG

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND & AIMS:The absence of grade A supporting evidence for surveillance colonoscopy in patients with ulcerative colitis (UC) has led to controversy regarding its benefit, yet it is routinely recommended in practice guidelines. Limited data are available on rates of colonoscopy surveillance and factors associated ...

journal_title：Gastroenterology

authors： Velayos FS,Liu L,Lewis JD,Allison JE,Flowers N,Hutfless S,Abramson O,Perry GS,Herrinton LJ

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND & AIMS:Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus characterized by dense tissue eosinophilia; it is refractory to proton pump inhibitor therapy. EoE affects all age groups but most frequently individuals between 20 and 50 years of age. Topical corticosteroids are effect...

journal_title：Gastroenterology

authors： Straumann A,Conus S,Degen L,Felder S,Kummer M,Engel H,Bussmann C,Beglinger C,Schoepfer A,Simon HU

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND & AIMS:Coffee is one of the most widely consumed beverages worldwide. Epidemiologic data indicate that coffee consumption protects against the progression of chronic liver disease and development of hepatocellular carcinoma and diabetes, but the mechanisms are not clear. UDP glucuronosyltransferases (UGT1A) ...

journal_title：Gastroenterology

authors： Kalthoff S,Ehmer U,Freiberg N,Manns MP,Strassburg CP

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND & AIMS:Estimates of complication rates following elective percutaneous liver biopsy vary and might not accurately reflect current practice. We studied mortality and complication rates, by indication, in patients after they underwent liver biopsies. METHODS:We performed a study using hospital episode statist...

journal_title：Gastroenterology

authors： West J,Card TR

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND & AIMS:Qualitative endoscopic ultrasound (EUS) elastography is an accurate but subjective tool for the differential diagnosis of solid pancreatic masses. Second-generation EUS elastography allows quantitative analysis of tissue stiffness. We evaluated the accuracy of quantitative, second-generation EUS elast...

journal_title：Gastroenterology

authors： Iglesias-Garcia J,Larino-Noia J,Abdulkader I,Forteza J,Dominguez-Munoz JE

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND & AIMS:Type 2 diabetes mellitus (DM) is associated with an increased risk of colorectal cancer (CRC); it is not clear if this association varies by sex or other factors. Insulin use might also be associated with CRC risk. We investigated associations of type 2 DM and insulin use with CRC risk. METHODS:The C...

journal_title：Gastroenterology

authors： Campbell PT,Deka A,Jacobs EJ,Newton CC,Hildebrand JS,McCullough ML,Limburg PJ,Gapstur SM

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND & AIMS:Mechanisms responsible for crypt architectural distortion in chronic ulcerative colitis (CUC) are not well understood. Data indicate that serine/threonine protein kinase Akt (Akt) signaling cooperates with Wingless (Wnt) to activate beta-catenin in intestinal stem and progenitor cells through phosphor...

journal_title：Gastroenterology

authors： Lee G,Goretsky T,Managlia E,Dirisina R,Singh AP,Brown JB,May R,Yang GY,Ragheb JW,Evers BM,Weber CR,Turner JR,He XC,Katzman RB,Li L,Barrett TA

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND & AIMS:Polymorphisms in the region of the interleukin (IL)-28B gene on chromosome 19 have been associated with peginterferon-alfa-induced clearance of genotype 1 hepatitis C virus (HCV); there are no data for patients with genotype 2 or 3 HCV. We evaluated the effects of IL-28B polymorphisms on response to t...

journal_title：Gastroenterology

authors： Mangia A,Thompson AJ,Santoro R,Piazzolla V,Tillmann HL,Patel K,Shianna KV,Mottola L,Petruzzellis D,Bacca D,Carretta V,Minerva N,Goldstein DB,McHutchison JG

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND & AIMS:Keratins 8 and 18 (K8/K18) provide anti-apoptotic functions upon liver injury. The cytoprotective function of keratins explains the overrepresentation of K8/K18 variants in patients with cirrhosis. However, K8/K18 variant-associated susceptibility to acute liver injury, which is well-described in anim...

journal_title：Gastroenterology

authors： Strnad P,Zhou Q,Hanada S,Lazzeroni LC,Zhong BH,So P,Davern TJ,Lee WM,Acute Liver Failure Study Group.,Omary MB

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND & AIMS:Adenosine mediates immune suppression and is generated by the ectonucleotidases CD39 (ENTPD1) and CD73 that are expressed on vascular endothelial cells and regulatory T cells (Tregs). Although tumor-infiltrating immune cells include Foxp3(+) Tregs, it is not clear whether local adenosine generation by...

journal_title：Gastroenterology

authors： Sun X,Wu Y,Gao W,Enjyoji K,Csizmadia E,Müller CE,Murakami T,Robson SC

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND & AIMS:Toll-like receptors (TLR) are innate immune receptors involved in recognition of the intestinal microflora; they are expressed by numerous cell types in the intestine, including epithelial cells, myeloid cells, and lymphocytes. Little is known about the relative contributions of TLR signaling in disti...

journal_title：Gastroenterology

authors： Asquith MJ,Boulard O,Powrie F,Maloy KJ

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND & AIMS:The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a transmembrane glycoprotein with pleotropic functions, including clearance of hepatic insulin. We investigated the functions of the related protein CEACAM2, which has tissue-specific distribution (kidney, uterus, and crypt epi...

journal_title：Gastroenterology

authors： Heinrich G,Ghosh S,Deangelis AM,Schroeder-Gloeckler JM,Patel PR,Castaneda TR,Jeffers S,Lee AD,Jung DY,Zhang Z,Opland DM,Myers MG Jr,Kim JK,Najjar SM

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND & AIMS:Seroclearance of hepatitis B surface antigen (HBsAg) is one of the most important clinical outcomes for chronic hepatitis B treatment trials. Few studies have explored the incidence and determinants of spontaneous seroclearance using a long-term follow-up study. This study aimed to examine the natural...

journal_title：Gastroenterology

authors： Liu J,Yang HI,Lee MH,Lu SN,Jen CL,Wang LY,You SL,Iloeje UH,Chen CJ,REVEAL-HBV Study Group.

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND & AIMS:The accurate identification of inactive (serum HBV-DNA persistently

journal_title：Gastroenterology

authors： Brunetto MR,Oliveri F,Colombatto P,Moriconi F,Ciccorossi P,Coco B,Romagnoli V,Cherubini B,Moscato G,Maina AM,Cavallone D,Bonino F

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND & AIMS:Narcotic bowel syndrome (NBS) is a subset of opioid bowel dysfunctions that results from prolonged treatment with narcotics and is characterized by chronic abdominal pain. NBS is under-recognized and its molecular mechanisms are unknown. We aimed to (1) develop a rat model of NBS and (2) to investigat...

journal_title：Gastroenterology

authors： Agostini S,Eutamene H,Cartier C,Broccardo M,Improta G,Houdeau E,Petrella C,Ferrier L,Theodorou V,Bueno L

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND & AIMS:Hemochromatosis is a common hereditary disease caused by mutations in HFE and characterized by increased absorption of iron in the intestine. However, the intestine does not appear to be the site of mutant HFE activity in the disease; we investigated the role of the liver-the source of the iron regula...

journal_title：Gastroenterology

authors： Garuti C,Tian Y,Montosi G,Sabelli M,Corradini E,Graf R,Ventura P,Vegetti A,Clavien PA,Pietrangelo A

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND & AIMS:Infection with Helicobacter pylori is associated with reduced risk of esophageal adenocarcinoma (EAC), but it is not clear whether this reduction is modified by genotype, other host characteristics, or environmental factors. Furthermore, little is known about the association between H pylori and adeno...

journal_title：Gastroenterology

authors： Whiteman DC,Parmar P,Fahey P,Moore SP,Stark M,Zhao ZZ,Montgomery GW,Green AC,Hayward NK,Webb PM,Australian Cancer Study.

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND & AIMS:We recently identified a polymorphism upstream of interleukin (IL)-28B to be associated with a 2-fold difference in sustained virologic response (SVR) rates to pegylated interferon-alfa and ribavirin therapy in a large cohort of treatment-naive, adherent patients with chronic hepatitis C virus genotyp...

journal_title：Gastroenterology

authors： Thompson AJ,Muir AJ,Sulkowski MS,Ge D,Fellay J,Shianna KV,Urban T,Afdhal NH,Jacobson IM,Esteban R,Poordad F,Lawitz EJ,McCone J,Shiffman ML,Galler GW,Lee WM,Reindollar R,King JW,Kwo PY,Ghalib RH,Freilich B,Nyberg

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND & AIMS:Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive and metastatic disease for which conventional treatments are of limited efficacy. A number of agents in development are potential anti-invasive and antimetastatic agents, including the Src kinase inhibitor dasatinib. The aim of this study wa...

journal_title：Gastroenterology

authors： Morton JP,Karim SA,Graham K,Timpson P,Jamieson N,Athineos D,Doyle B,McKay C,Heung MY,Oien KA,Frame MC,Evans TR,Sansom OJ,Brunton VG

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatopulmonary syndrome (HPS) affects 10%-30% of patients with cirrhosis and portal hypertension and significantly increases mortality. Studies in experimental models indicate that pulmonary angiogenesis contributes to the development of HPS, but pathogenesis in humans is poorly understood. We invest...

journal_title：Gastroenterology

authors： Roberts KE,Kawut SM,Krowka MJ,Brown RS Jr,Trotter JF,Shah V,Peter I,Tighiouart H,Mitra N,Handorf E,Knowles JA,Zacks S,Fallon MB,Pulmonary Vascular Complications of Liver Disease Study Group.

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis B virus (HBV) and hepatitis C virus (HCV) can be transmitted during administration of intravenous anesthesia when medication vials are used for multiple patients using incorrect technique. We investigated an outbreak of acute HBV and HCV infections among patients who received anesthesia duri...

journal_title：Gastroenterology

authors： Gutelius B,Perz JF,Parker MM,Hallack R,Stricof R,Clement EJ,Lin Y,Xia GL,Punsalang A,Eramo A,Layton M,Balter S

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND & AIMS:We aimed to identify the incidence and predictors of de novo gastroesophageal variceal formation and progression in a large cohort of patients with chronic hepatitis C and advanced fibrosis. METHODS:All participants in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis Trial were offered...

journal_title：Gastroenterology

authors： Fontana RJ,Sanyal AJ,Ghany MG,Lee WM,Reid AE,Naishadham D,Everson GT,Kahn JA,Di Bisceglie AM,Szabo G,Morgan TR,Everhart JE,HALT-C Trial Group.

更新日期：2010-06-01 00:00:00

abstract：:A variety of noninvasive molecular approaches to colorectal cancer screening are emerging with potential to improve screening effectiveness and user-friendliness. These approaches are based on the sensitive assay of molecular markers in stool, blood, and urine samples. New methods, especially next generation stool-bas...

journal_title：Gastroenterology

authors： Ahlquist DA

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND & AIMS:Limited evidence suggests that proton pump inhibitors (PPI), nonsteroidal anti-inflammatory drugs (NSAID)/aspirin, and statins may be associated with a low risk of esophageal neoplasia. However, the possible effect these medications may have on the risk of esophageal adenocarcinoma (EAC) in patients w...

journal_title：Gastroenterology

authors： Nguyen DM,Richardson P,El-Serag HB

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND & AIMS:Two percent to 4% of all cases of colorectal cancer (CRC) are associated with Lynch syndrome. Dominant clustering of CRC (non-Lynch syndrome) accounts for 1%-3% of the cases. Because carcinogenesis is accelerated in Lynch syndrome, an intensive colonoscopic surveillance program has been recommended si...

journal_title：Gastroenterology

authors： Vasen HF,Abdirahman M,Brohet R,Langers AM,Kleibeuker JH,van Kouwen M,Koornstra JJ,Boot H,Cats A,Dekker E,Sanduleanu S,Poley JW,Hardwick JC,de Vos Tot Nederveen Cappel WH,van der Meulen-de Jong AE,Tan TG,Jacobs MA,Mohame

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND & AIMS:The molecular basis underlying visceral hypersensitivity in functional irritable bowel syndrome remains elusive, resulting in poor treatment effectiveness. Because alterations in spinal non-neuronal (astrocytic) glutamate reuptake are suspected to participate in chronic pain, we asked whether such pro...

journal_title：Gastroenterology

authors： Gosselin RD,O'Connor RM,Tramullas M,Julio-Pieper M,Dinan TG,Cryan JF

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND & AIMS:Approximately half of the families that fulfill Amsterdam criteria for Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) do not have evidence of the germline mismatch repair gene mutations that define this syndrome and result in microsatellite instability (MSI). The carcinogenic path...

journal_title：Gastroenterology

authors： Goel A,Xicola RM,Nguyen TP,Doyle BJ,Sohn VR,Bandipalliam P,Rozek LS,Reyes J,Cordero C,Balaguer F,Castells A,Jover R,Andreu M,Syngal S,Boland CR,Llor X

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND & AIMS:Cholecystokinin (CCK) is a satiation peptide released during meals in response to lipid intake; it regulates pancreatic digestive enzymes that are required for absorption of nutrients. We proposed that mice with a disruption in the CCK gene (CCK knockout [CCK-KO] mice) that were fed a diet of 20% butt...

journal_title：Gastroenterology

authors： Lo CM,King A,Samuelson LC,Kindel TL,Rider T,Jandacek RJ,Raybould HE,Woods SC,Tso P

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND & AIMS:Body weight (BW) loss and reduction of blood ghrelin level are commonly observed after total gastrectomy (TG). A prospective study was designed to elucidate whether exogenous ghrelin administration prevents postoperative BW loss by improving appetite and oral food intake in patients with gastric cance...

journal_title：Gastroenterology

authors： Adachi S,Takiguchi S,Okada K,Yamamoto K,Yamasaki M,Miyata H,Nakajima K,Fujiwara Y,Hosoda H,Kangawa K,Mori M,Doki Y

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND & AIMS:Screening colonoscopy is an effective method to reduce the incidence of and mortality from colorectal cancer (CRC). There is little empirical evidence available about the optimal interval for screening, making this a subject of debate. We associated the prevalence of advanced colorectal neoplasms with...

journal_title：Gastroenterology

authors： Brenner H,Haug U,Arndt V,Stegmaier C,Altenhofen L,Hoffmeister M

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND & AIMS:Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase-C receptor that stimulates intestinal fluid secretion and transit and reduces pain in animal models. We assessed the safety and efficacy of a range of linaclotide doses in patients with chronic constipation. METHODS:We perfo...

journal_title：Gastroenterology

authors： Lembo AJ,Kurtz CB,Macdougall JE,Lavins BJ,Currie MG,Fitch DA,Jeglinski BI,Johnston JM

更新日期：2010-03-01 00:00:00